besides selective serotonin reuptake inhibitors (SSRI), there's 1 more class of antidepressants that is in vogue and readily prescribed, the serotonin–norepinephrine reuptake inhibitors (SNRI)
i'll go through that and also through norepinephrine-dopamine reuptake inhibitors (NDRI), serotonin–norepinephrine–dopamine reuptake inhibitors (SNDRI) and dopamine reuptake inhibitor (DRI).
SNRIs are: milnacipran, duloxetine, levomilnacipran, bicifadine, desvenlafaxine, sibutramine and, the most potent of them is venlafaxine, which i'll be focusing on now. the IMS Health rating from 2009 lists venlafaxine at no.9 among the most frequently prescribed psychiatric medications within the US.
-http://psychcentral.com/lib/top-25-psychiatric-prescriptions-for-2009/0003170
if you happen to get a prescription for an SNRI, it'll probably be for this one, which, conveniently enough, "seems to be more dangerous in overdose than the SSRIs, except perhaps citalopram which is more dangerous than the other SSRIs in overdose."
-http://en.wikipedia.org/wiki/Venlafaxine
based on a fatality report reported to us from the medical University of South Carolina, from 2003,
"a 39-year-old woman with a history of depression and suicidal ideations came to the emergency department after intentionally ingesting approximately 30 g of extended-release venlafaxine capsules. family members postulated that she had ingested the capsules 12-24 hours before coming to the emergency department [...] the patient was transferred to the medical intensive care unit, where vasopressor therapy with dopamine was started [...] she required multiple courses of treatment with broad-spectrum antibiotics for persistent fever [...] her clinical condition continued to deteriorate, and she died on day 43"
-http://www.medscape.com/viewarticle/465884_2
it follows, you'd need to take 400 of the 75mg venlafaxine capsules, or 200 of the 125mg capsules (both adding up to 30g) to reach a fatal overdose. it might take a long time to die, which, won't matter so much to yourself, though, because a potentially severe overdose leads to severe CNS depression. you'd be in a coma. of course, you'll be keeping the hospital staff (provided that you'll be delivered to a hospital) busy and your family/friends in suspense. but of course, that's not necessarily a bad thing.
but, if you happen to have diabetes mellitius, a smaller dose might suffice
"a 40-year-old male with a history of non–insulin-dependent diabetes mellitus [...] after itentionally ingesting ninety 150-mg venlafaxine [...] and seventy-five 75-mg venlafaxine […] the total amount ingested was 19g [...] [was, ] on initial presentation [...] asymptomatic except for nausea ...] the patient arrived at the tertiary ED 3.5 hours post-ingestion. he became progressively more lethargic, and approximately 9 hours post-ingestion developed refractory ventricular fibrillation (VF) and subsequently expired"
-http://jmt.pennpress.org/strands/jmt/pdfHandler.pdf;jsessionid=
9C6EFBA5F6C0EC58B4CB82581089A6A2?issue=20080401&file=20080401_018_020.pdf
it isn't quite clear whether diabetes mellitius played a role. maybe a non-diabetic person would also die with no more than 19g
just for your information, "venlafaxine [...] appears less dangerous than bupropion"
-http://en.wikipedia.org/wiki/Venlafaxine
let's take a look at bupropion then. according to the IMS Health rating from 2009, it's the no.14 of the most frequently prescribed psychiatric medications within the US
-http://psychcentral.com/lib/top-25-psychiatric-prescriptions-for-2009/0003170
if taken in large quantities, it leads to cardiac arrest/respiratory failure
-www.rxlist.com/wellbutrin-drug/overdosage-contraindications.htm
less than 10g are sufficient to bring your life to an end, as a few success stories tell us
-http://jat.oxfordjournals.org/content/17/7/436.short
if not fatal, it should at least lead to loss of consciousness, so you can mix it with some other method that would be too painful by itself.
in 2008 "a 35-year-old male was found lying in his bed about 72 h after he died. An empty box of [...] 30 slow-release tablets of 150 mg of BUP was near the body [...] no other known medication was involved."
-http://jat.oxfordjournals.org/content/32/2/192.full.pdf
that's a dose of 4.5g. to play it safe, take 67 150mg tablets instead (which more or less sum up to 10g) similar to the situation with SSRIs, bupropion can be mixed with MAOIs to lessen the risk of survival. and it also can be mixed with citalopram (introduced in 025) to increase the toxicity of citalopram. bupropion belongs to (and is the most potent of) the NDRIs, of which there's a lot. of the ones currently used for medical treatments, there's, besides the one in question here, dexmethylphenidate, fencamfamine, methylphenidate, prolintane, pyrovalerone. of the one's currently in use as designer drugs, there's diphenylprolinol and methylenedioxypyrovalerone.
also worth a mention is the research chemical amfonelic acid, which is "not a controlled substance in the United States, and thus is legal to possess. it is available from many biotechnology supply companies"
-http://en.wikipedia.org/wiki/Amfonelic_Acid
and is price-wise ok. $88.88 per gram.
there's not much information on this still new substance, and how much you'd need to die, but let's investigate and speculate.
dog_on_acid's self-test says that a dose of "20mg [...] produced nothing [...] well almost nothing. i felt a slight rise in energy and euphoria but close to maybe one cup of coffee or 40mg speed [...] the next day I pushed it to 30. there was definite action here [...] it was subtle but I was very aware of the smaller details of life. i was processing information faster, i was happier, euphoric you could say and to a substantial degree [...] after an hour or so I jumped another barrier and insufflated 10mg [...] it only seemed to extend the action, possibly elevating it only slightly [...] a perfect dose [...] is between 30 and 40mg"
-http://www.reddit.com/r/Nootropics/comments/1f4z0j/amfonelic_acid/
by comparison, a "perfect" (= typical) dose of cocaine lies between 50 and 150mg.
in Izenwasser's, Werling's and Cox'es comparison of dopamine inhibitors, amfonelic acid "biphasically inhibited uptake (of dopamine) in the striatum, nucleus accumbens and olfactory tubercle with [...] amfonelic acid being approximately 50-fold more potent than cocaine or methylphenidate"
-https://www.ncbi.nlm.nih.gov/pubmed/2145054
as far as the medial prefrontal cortex is concerned, there seems to be no inhibitory difference between GBR 12909 (aka vanoxerine, a DRI) and cocaine. vanoxerine and amfonelic acid seem to be generally equivalent,
though, as dopomine ihibitors. this lets us assume that in some areas of the brain amfonelic acid inhibits dopamine much more thoroughly than cocaine, while in others there's probably no difference. "45mg [...] really is the upper end of the scale, which is what I wanted to experience but not quite to this
extent", says dog_on_acid, while 150mg is the upper end of the scale for cocaine.
does this mean, amfonelic acid is around 3 times as potent as cocaine? possibly.
and if it were so, just a few grams of amfonelic acid would suffice to kill a person.
DRIs:
they are primarily used by researchers and don't generally find medical applications, but difluoropine "is not explicitly illegal anywhere in the world as of 2008, but might be considered to be a controlled substance analogue of cocaine on the grounds of its related chemical structure, in some jurisdictions such as the USA, Canada, Australia and New Zealand."
-http://en.wikipedia.org/wiki/Difluoropine
also RTI-229 "is legal throughout the world as of 2010. Some jurisdictions such as the USA, Australia and New Zealand might however consider RTI-229 to be a controlled substance analogue of cocaine on the grounds of its related chemical structure."
-http://en.wikipedia.org/wiki/RTI-229
you could possibly get hold of the 2 substances above.
labeled as designer drugs are methoxetamine and methoxydine, also potentially obtainable, from your drug dealer of trust.
vanoxerine aka GBR-12909, which, has already been compared to amfonelic acid a few moments earlier, is (at the time of writing this = 2014) being investigated for its potential benefits in treating cardiac arrhythmias. it might or might not see some medical use someday. if it does, you could induce some arrhytmia via conium or aconitum seeds, then go to see your doctor, and demand a medication (the brand new vanoxerine!) that'll stabilize your heart rhythm.
SNDRIs:
there's only one on the medical market, nefopam (for use as a non-opiod analgesic agent). and there's 3 naturally occuring SNDRIs, which will be covered soon.
"nefopam is approximately 10 times more potent than aspirin and 2 to 3 times less potent than morphine."
-Puchnarewicz's, Button's, D Lee's and Holt's case report @ http://www.the-ltg.org/data/uploads/posters/puchnarwicz.pdf
and it can be mixed with SSRIs or MAOIs to enhance the toxic effect. ("there is the potential for serotonin syndrome or hypertensive crises to result")
-http://en.wikipedia.org/wiki/Nefopam
"a 37-year-old caucasian female, who had worked as a nurse in a medical erhabilitation unit, was found lying on the floor dead at home. the body was markedly putrefied (estimated time since death: 7-10 days [...]) and covered with numerous fly larvae. no signs of violence were observed. fifteen broken ampules of acupan (equivalent to 300mg nefopam) were found near the body, together with a used syringe equipped with an i.v. needle."
- Traqui's, Berthelon's and Lude's case report @ http://www.deepdyve.com/lp/oxford-university-press/fataloverdosage-with-nefopam-acupan-Si0U0iuBtv
one needs to consider, that, an intrevenous intake usually needs less drug to kill than an oral intake. a tablet has 30mg.
"dosage may range from 1 to 3 tablets three times daily depending on response. the recommended starting dosage is 2 tablets three times daily. "
-http://www.medsafe.govt.nz/profs/datasheet/a/acupantabinj.pdf
as far as injections are concerned, "20 mg (1 ml) intramuscularly repeated if necessary every six hours (see instructions for administration). onset of effect after intramuscular injection is within 15 to 20 minutes and peak effect is reached one to one-and-a-half hours after administration."
-same source as above
one ampule has 20mg (x 15 = 300mg = fatal dose) while 3 tablets amount to 90mg (x 15 = 1350mg = fatal dose). you'd need 45 tablets.
hypericum perforatum "is widely known as an herbal treatment for depression",
-http://en.wikipedia.org/wiki/Hypericum_perforatum
probably because of the phytochemicals hyperforin and adhyperforin that it carries within itself.
(ad)hyperforin is, among other effects that is produces, a natural SNDRI. "over-the-counter (OTC) drugs are medicines sold directly to a consumer without a prescription"
-http://en.wikipedia.org/wiki/Over-the-counter_drug
and so are hypericum perforatum herbal extracts. but they might not be as potent as they claim to be. Laif900 is a product of this type that has a hyperforin content of 5,75mg to 8,64mg (although it says on the package there's 18mg in a tablet), based on a study-report from 2002, conducted by some researcher in the Universität Frankfurt.
-http://www.pharmazeutische-zeitung.de/index.php?id=23988
hyperforin acts as a reuptake inhibitor of (e.g.) dopamine, to some extent. it does have a slight effect on the reuptake of serotonin, too, and in high doses can bring about a mild serotonine syndrome. mixed with other
antidepressants (of the SSRI class) it might lead to a deadly serotonine syndrome. mixed with yet others (of the DRI, NDRI or SNDRI class) it can possibly enhance the effect of these.
2% is the (ad)hyperforin content in the blossoms, 4% in the fruits.
-http://de.wikipedia.org/wiki/Echtes_Johanniskraut
a selfmade, 2g teabag of hypericum perforatum blossoms would contain 40mg hyperforin. that's so little, you'd be better off buying those tablets.
"in the early hours of the morning a 20-year-old girl was taken to the ED of the local hospital where, shortly thereafter, was pronounced dead. as told by her boyfriend, the evening before, they bought a dose of about 5 grams of cocaine; at around 8.30pm they were stopped by the police agents for control. the girl, in fear of a drug arrest, ingested the polyethylene wrapper containing the drug. Once back home, the girl made several attempts to expel the wrapper by vomiting. although the boy-friend tried to bring her to the hospital, she asserted to feel good, so they went to sleep. at around 2.40 a.m. the boy-friend was woken up because the girl was “strongly shaken” by convulsions. promptly carried to hospital, the girl arrived around 3.00 a.m.
at ED with severe agitation [...] and unconsciousness [...] at 3.10 a.m. she died"
-http://www.droganews.com/pubdownload.php?id=2458
the preceding was a case that occured in 2010, as published by Barbera, Romano and Spadaro in their "lethal cocaine intoxication due to bodystuffer syndrome”
it is known that some people can survive the ingestion of several grams. but also that people died after a meal of less than 5g. what to aim for? 10g is my recommendation.
the alkaloid content of coca leaves is low, between 0.25% and 1.5%.
-http://en.wikipedia.org/wiki/Coca
if you were to extract cocaine yourself, you'd need (assuming the concentration is only 0.25%) 4kg of source material (= leaves from grown up trees). that's a lot of work (plucking such an amount of leaves and then
subjecting them to chemical reactions), and, on top of that, if you happen to live outside of Colombia, Peru or Bolivia, it's unlikely you'll ever bump into a coca tree anyway. so your best point of reference would be a drug dealer who has ready-to-consume stuff of this sort ready for you.
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