-http://en.wikipedia.org/wiki/Chinese_herbology
"cardiomyopathy (literally "heart muscle disease") is the measurable deterioration of the function of the myocardium (the heart muscle) for any reason, usually leading to heart failure; common symptoms are dyspnea (breathlessness) and peripheral edema (swelling of the legs)"
-http://en.wikipedia.org/wiki/Cardiomyopathy
the taste, apparently, is: bitter & hot
ephedra is a medicinal preparation from the má huáng (麻黃, ephedra sinica), the most potent of the ephedra plants. it isn't commonly sold in most countries, and if it is, it's usually bound to prescriptions, unless it's part of a medicine with a very low ephedrine content (e.g. Wick MediNait, 26,7mg per 100ml)
ephedra plants contain plenty of alkaloids. ephedrin makes up something between 6.4mg and 21,4mg in 100g of ephedra sinica
-"Risikobewertung von Pflanzen und pflanzlichen Zubereitungen" p. 225, http://www.bfr.bund.de/cm/350/risikobewertung-von-pflanzen-und-pflanzlichen-zubereitungen.pdf
which is not much. in all the other ephedra plants, the content is even lower. but i'll come back to this in a moment
there is some potential for a potentially fatal hypertonia, if ephedrine is combined with MAOIs.
-"Risikobewertung von Pflanzen und pflanzlichen Zubereitungen" p. 235, http://www.bfr.bund.de/cm/350/risikobewertung-von-pflanzen-und-pflanzlichen-zubereitungen.pdf
and mixed with caffeine, ephedrine's toxicity gets increased.
EC(A) stacks, which are drug combinations, combining caffeine and ephedrine (and aspirin), once were sold as appetite suppressants, but are now illegal in the US, Canada and the Netherlands, because of too many death reports.
if you can't find them in your country, they can still be ordered from abroad. 1 capsule contains 25mg of ephedrine and 200mg of caffeine.
-http://www.eca-stack-deals.com/ECA-Stacks-mit-Ephedra/ECA-Xtreme-Der-klassische-ECA-Stack-mit-Ephedra--46.html?MODsid=fnn3fpuo8hkbpm62kqi4gd0jl1
"blood or plasma ephedrine concentrations are typically in the 20-200 µg/L range in persons taking the drug therapeutically, 300-3000 µg/L in abusers or poisoned patients and 3–20 mg/L in cases of acute fatal overdosage."
-http://en.wikipedia.org/wiki/Ephedrine
in other words, to end up dead, you'd need to take 100 (or more, or less, since there's caffeine in it) times the normal dose (which is 1 capsule). so 100 capsules (or more, or less). and 1 capsule may have the ephedrine content of 400g raw plant material (as far as the ephedra sinica is concerned)
just to give you an idea, if you can't get hold of these not-everywhere-legal EC(A) stacks, you'd need 40kg of ephedra sinica instead. that's a whole meadow. hardly worth the trouble of growing that much (or at least that's what it would seem to most people), of reaping it, and of extracting the alkaloid. let's move on.
traditional Chinese medicine's herbology offers some excellent ways to cause hepatotoxicity (chemical-driven liver damage), if not even acute liver failure. this can be achieved via...
hé shǒu wū (何首乌, fallopia multiflora), which contains anthraquinone
or via...
comfrey plants. "some scientists and physicians agree that the use of comfrey should be restricted to topical use, and should never be ingested, as it contains dangerous amounts of hepatotoxic pyrrolizidine alkaloids"
-http://en.wikipedia.org/wiki/Symphytum_%C3%97_uplandicum
the aforementioned alkaloids can also be found in senecio nemorensis and in senecio cannabifolius var. integrilifolius
let's go through the aforementioned, anthraquinone can be bought in 1.1ml ampoules, by everyone, probably all over the world. but there's not the slightest hint as to the lethal dose.
"an overdose or overusage of anthraquinones may cause vomiting, intestinal spasms and bloody diarrhea"
-http://www.herbaltransitions.com/materiamedica/Rheum.htm
liver (or/and possibly kidney) damage comes last on the list. before i show you what a successful handling of such a substance looks like, let me mention, that, besides the original anthraquinone, there's also "senna glycosides or sennosides [...] a number of anthraquinone derivatives useful as a laxative [...] named after their abundant occurrence in plants of the genus senna"
-http://en.wikipedia.org/wiki/Senna_glycosides
"a 52-year-old woman who had ingested, for >3 years, one liter of an herbal tea each day made from a bag containing 70 g of dry senna fruits, developed acute hepatic failure and renal impairment requiring intensive care therapy. the severity of the hepatic failure was reflected by the increase in prothrombin time (international normalized ratio >7) and the development of encephalopathy. liver transplantation was discussed, but the patient ultimately recovered with supportive therapy"
-http://www.ncbi.nlm.nih.gov/pubmed/15956233
hepatic failure is liver failure,
prothrombin is "an essential component of the blood-clotting mechanism. prothrombin is transformed into thrombin by a clotting factor known as factor X or prothrombinase; thrombin then acts to transform fibrinogen, also present in plasma, into fibrin, which, in combination with platelets from the blood, forms a clot."
-http://www.britannica.com/EBchecked/topic/480073/prothrombin
encephalopathy, "in some contexts it refers to permanent (or degenerative) brain injury, and in others it is reversible."
-http://en.wikipedia.org/wiki/Encephalopathy
so there you have it. constantly, conscientiously, consume drinks containing anthraquinone or a derivate of it, and 3 (or so) years later, you can reap the reward.
pyrrolizidine alkaloidosis "is a disease caused by chronic poisoning [...] caused by ingesting poisonous plants which contain the natural chemical compounds known as pyrrolizidine alkaloids [it] can result in damage to the liver, kidneys, heart, brain, smooth muscles, lungs, DNA, lesions all over the body, and could be a potential cause of cancer"
-http://en.wikipedia.org/wiki/Pyrrolizidine_alkaloidosis
based on the official recommendation in Germany, people should ingest no more than 1µg daily. pyrrolizidine alkaloids, at first, are harmless. it isn't until they reach the liver that they start to act out their toxic effect.
-a detailed description of this process can be found here: http://www.musbed.com/tr/DergiPdf/af0a4c544df44fc19459a0d397578f66.pdf
if you happen to be pregnant, an intake of even 7µg will probably do no harm to you. it will, however, kill your foetus. "in 2003 it was shown (Rasenack, Müller, et al.) that the daily uptake of ~ 7 µg PA (from a herbal tea containing comfrey) during pregnancy did not show a toxic effect in the mother´s liver but damaged the foetal liver in such a way that the newborn child died after 2 days"
-http://peer.ccsd.cnrs.fr/docs/00/67/36/72/PDF/PEER_stage2_10.1080%252F19440049.2010.541288.pdf
"a liver disease of unknown etiology, called unknown liver disease (ULD) [...] was first identified in 2002 in Tigray; a rugged, semi-arid, mountainous region that is considered one of the most drought-prone and food insecure regions of Ethiopia. [...] after several investigations, a local plant containing a particular type of pyrrolizidine alkaloid (PA) toxin that contaminated local foodstuffs was identified as the etiologic agent, and ULD was renamed PAILD in 2011"
-"evaluation of the pyrrolizidine alkaloid induced liver disease (PALID)", http://ojphi.org/article/download/4560/3579
a sureveillance system had been implemented there in 2009 "with the objectives to determine the magnitude and distribution of the disease [...] the system identified a total of 1033 cases, including 314 deaths, as of September 2011"
-"evaluation of the pyrrolizidine alkaloid induced liver disease (PALID)", http://ojphi.org/article/download/4560/3579
so a long-term use of teas based on pyrrolizidine containing herbs, will, similar to a long-term anthraquinones consumption, eventually lead to liver damage, or even failure.
having aquired organ failure, it's still a long way to death. it can take weeks, and during this period (of agony), you could get rescued via medical treatment or a transplantation. to speed things up, maybe you could throw in some paracetamol.
not only does traditional Chinese medicine's herbology offer some excellent ways to cause hepatotoxicity (chemical-driven liver damage), if not even acute liver failure, but traditional Chinese medicine's herbology also offers some excellent ways to cause cancer, and, nephropathy (damage to or disease of a kidney), if not even acute kidney failure. this can be achieved via...
aristolochia, which "has been shown to be both a potent carcinogen and kidney toxin"
-http://en.wikipedia.org/wiki/Aristolochia
a carcinogen, btw, "is any substance, radionuclide, or radiation that is an agent directly involved in causing cancer"
-http://en.wikipedia.org/wiki/Carcinogen
if it won't kill you, it'll lower your life expectancy
besides aristolochia, asarum canadense also contains the lethal toxin aristolochic acid.
"a 48-year-old male was referred to our university hospital for severe azotemia with muscle cramp. he had been taking Chinese herbs as a traditional medicine to reduce hyperuricemia for about 9 months [...] hemodialysis was conducted and his general condition improved [...] aristolochic acid was detected in the Chinese herbs, leading to the diagnosis of aristolochic acid nephropathy (AAN). his renal dysfunction was considered to be irreversible and he underwent maintenance hemodialysis"
-http://www.ncbi.nlm.nih.gov/pubmed/15971892
azotemia, from "azot" (= nitrogen) + "-emia" (= blood condition), "is a medical condition characterized by abnormally high levels of nitrogen-containing compounds [...] in the blood"
-http://en.wikipedia.org/wiki/Azotemia
hemodialysis "is a method that is used to achieve the extracorporeal removal of waste products [...] from the blood when the kidneys are in a state of renal failure"
-http://en.wikipedia.org/wiki/Hemodialysis
of all the aristolochiaceae, the (more or less) exact amounts of aristolochic acid have been documented for the aristolochia clematitis. the rhyzome, as well as the root contain up to 0.7%, the seeds up to 0.43%. the leaves up to 0.03%.
-"Hagers Handbuch der pharmazeutischen Praxis", p.171, http://books.google.de/books?id=eoltv16gtZQC&pg=PA171#v=onepage&q&f=false
tea made out of leaves will be way to mild. instead, since ready-to-buy aristolochic acid is not easily available, you could make your own herbal medicine, as follows:
mix distilled water with alcohol. so you'll get a low percentage alcohol. hackle some of the more potent parts of the aristolochia clematitis, pestle it for about 1 hour. the result you get out of your work should make its way into a little bottle. pour the low percentage alcohol over it, so that the bottle gets filled to around 2 thirds (66%). you're done.
this is based on Anja Alijah Flick's recipe.
-http://www.vorsichtgesund.de/glossary/osterluzei-aristolochia-clematitis/
her dosage recommendation is 3-5 drops for each day.
my dosage recommendation is 1 or more bottles for each day.
renal failure won't come soon. but i guess, it'll take less than 9 months if you follow my recommendation.
to speed things up, maybe you could drink some dolce vino.
summa summarum, traditional Chinese medicine can destroy your body, but it takes a while. only the ephedra (e.g. as in those EC(A) stacks) could lead to a quick (and therefore not bound to much agony) lieto fine.
ciononostante, you could aswell start drinking those herbs. what do you have to lose? that is, besides your liver and/or kidneys. with each passing day, it will bring you closer to your goal.
if you can't find ready-to-buy ephedra, you could grow the ephedra sinica, ephedra shennungiana, or any other equivalent ephedra species. plant yourself. "the plant is harvested as late as possible after the last rain, but before the winter frost and is air-dried in the sun."
-"PDR for herbal medicine", p.488
which is in autumn. the root, the rhyzome, and the branchlets then need to be dried.
the amount of plant you'll need to ingest is >100g, "corresponding to approximately 1 to 2 gm L-ephedrine"
-"PDR for herbal medicine", p.489
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