027 over-the-counter sleep aids

most over-the-counter sleeping pills are useless. but there's 2 exceptions. 2 antihistamines.

doxylamine, "the most effective over-the-counter sedative available in the United States and is more sedating than some prescription hypnotics"
-http://en.wikipedia.org/wiki/Doxylamine

"fatalities have been reported from doxylamine overdose. these have been characterized by coma, tonic-clonic (or grand mal) seizures and cardiorespiratory arrest."
-http://en.wikipedia.org/wiki/Doxylamine

you're not supposed to mix this with MAOIs, unless, of course, you want to die.

a typical tablet contains 30mg of doxymaline succinate, that's apparently 20.88mg of pure doxylamine

the median lethal dose is thought to lie somewhere between 25mg/kg* and 500mg/kg*
* = body weight in kg

if you're an average 60kg person, you'd need 1500mg (= 78 tablets) al minimo - to have an outlook for death to begin with. and 30g of doxylamine (= 1560 tablets) to have an (at least) 50% chance for success.

it's to be expected that you'll underdose your overdose with doxylamine, and survive, but, as a means to induce sleep - so that some other toxic substance can do the main work while you're unconscious - it's still worth a look, if you can't get hold of a barbiturate/benzodiazepine.

diphenhydramine, "the drug has a strong hypnotic effect and is FDA-approved as a non-prescription sleep aid"
-http://en.wikipedia.org/wiki/Diphenhydramine

it, furthermore, "inhibits post-synaptic reuptake of serotonin"
-http://journal.publications.chestnet.org/article.aspx?articleid=1094281

and thus can be mixed with SSRIs and/or MAOIs to induce SS.

a typical tablet contains either 50mg or merely 25mg. this is what might happen to you if you take 1200mg

"in about 3 large gulps with water. all 48 pills were taken [...] from what i can remember all the classic effects I loved were there faster then normal. but a more stronger effect of nervousness was there [...] then pure panic hit. for no real reason just panic. i kept looking behind me, at the door and into the empty spaces of my room [...] after an unknown amount of time i was experiencing full on hallucinations in a delirious state with out realising it. i also remember looking around my room and seeing a frightening figure looking at me. the absolute worst part of the whole trip came from a trip to the bathroom. at the time i did not realise it but i drank a gulp of "calgone take me away" body spray. i did not even know i was in the bathroom. i only know i did this because i remember haveing a terrible taste and trying to gasp for air. from here on is a total blackout. the next thing i remember is 5 hours later. i asked a relative what had happened
[...] apparently i left the bathroom shower on all night, dropped a lot of music cds on the floor and was running around the house without a shirt."
-ziggyjuarez, http://www.bluelight.org/vb/threads/383024-Diphenhydramine-(1-200mg)-Experienced-Dont-Take-this-much-Ever

as you see, this dose merely alters your perception, and is not enough to force a nap onto you. higher doses, presumably, could achieve this, and maybe even prevent you from ever waking up again, like some documented diphenhydramine-only-fatal-overdose cases demonstrate. but it's unclear what tablet amounts you should aim for. well, you should certainly take more than 1200mg

it may be that none of the above will manage to put you to sleep. be it temporarily or permanently.

but, Spain offers 2 other relatively attractive sleep aids, available for purchase without prescription, e.g. here:
http://pharmaonline.tv/index.php?cat=c25_sleeping-pills-sleeping-pills.html

zopiclone, a nonbenzodiazepine hypnotic, "has a similar fatality index as benzodiazepine drugs" 
-http://en.wikipedia.org/wiki/Zopiclone

there's fatal case reports, reporting the cases of people with respiratory problems, who managed to put an end to these problems via zopiclone, as well as the cases of people who enjoyed a self-made alcoholic zopiclone beverage. there is no data telling us what the lethal dose of zopiclone (in it's pure form) is. but it's thought to be lethal all by itself in high amounts.

"a 24-year-old Caucasian [...] had attended a party on the night of her death. she phoned a male friend and fell asleep while talking to him. the friend ended the conversation at 0200 h. She was found dead at 1940 h in her bedroom by her parents. she had been bleeding from the mouth and nose and was discovered next to a plastic drink bottle containing liquid and tablet residues. the cause of death was zopiclone overdosage complicated by ethanol use [...] the zopiclone blood concentrations [...] were at least 30 times the expected plasma concentration after single oral dosage [...] the blood ethanol concentration of 185 mg/dL may well be a contributing factor [...], although there have been claims that zopiclone, in contrast to benzodiazepines, does not have additive central nervous system depressant effects with ethanol"
-Boniface's and Russell's case report, http://jat.oxfordjournals.org/content/20/2/131.full.pdf

she took 30 times the "expected" dose, and some alcohol, which might or might not have increased the toxicity.

ordinary tablets contain 7.5mg each, and 30 of them are in one package. that's quite convenient. it seems, 30 is all you need.

chlormethiazole, a sedative and hypnotic, more potent than some benzodiazepines, today "marketed either as a free base in an oily suspension containing 192 mg in capsule form, or as clomethiazole edisylate syrup."
-http://en.wikipedia.org/wiki/Clomethiazole

"chlomethiazole is particularly toxic and dangerous in overdose and can be potentially fatal. Keith Moon (1946-1978), drummer of the renowned English rock band The Who, died after taking an overdose of clomethiazole on September 7, 1978. [...] as the drug can be fatal in high doses, prescribing clomethiazole outside a controlled environment, like a hospital, is not recommended, especially because there are much less toxic alternatives, such as diazepam. diazepam is one of many drugs belonging to the benzodiazepine" 
-http://en.wikipedia.org/wiki/Clomethiazole

"he wanted to get sober, but due to his fear of psychiatric hospitals he wanted to do it at home. clomethiazole is discouraged for unsupervised detoxification because of its addictive potential, its tendency to induce tolerance and its risk of death when mixed with alcohol the pills were prescribed by Geoffrey Dymond, a physician who was unaware of Moon's lifestyle. Dymond prescribed a bottle of 100 pills, instructing him to take one pill when he felt a craving for alcohol but not more than three pills per day"
-http://en.wikipedia.org/wiki/Keith_Moon

Keith, btw, instead of 1 or 3, took 32 pills.

they sell packages with 30. i guess 1 package would suffice to induce sleep. and mixed with alcohol, to induce permanent sleep.

4 comments:

  1. here's another fatal chlormethiazole (aka Heminevrin) overdose:

    "a doctor prescribed 60 tablets to a suicidal patient without seeing him just two days before he used them to kill himself, an inquest heard [...] Mr Donohue [...] died in December 2002 after taking the Heminevrin tablets - which are used to treat alcohol withdrawal symptoms - with whiskey.
    Dr Sreedharan [...]: "i did not see the patient. his mother telephoned [...] at first I said she couldn't have a prescription until I had seen him but the mum said he didn't need a visit. i told the mother that if he took the medication Heminevrin and alcohol it would kill him but she said she would make sure he didn't drink [...] i was put in a situation where I couldn't do any more than issue the medication. i couldn't be a hard-hearted man to a caring mother. "
    -http://www.manchesterusersnetwork.org.uk/2011/06/17/prescribed-60-tablets-without-seeing-the-patient/

    he took 60 chlormethiazolethem with whisky

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  2. pausinystalia yohimbe, the main alkaloid in the bark is yohimbine

    which, is present there in concentrations between 7-115 mg/g. on the average 10 mg/g (which is 1%)
    -etz et al., 1995; Zanolari et al., 2003; HagerROM, 2006; Chen et al., 2008

    "In case of overdose, weakness, generalised paraesthesia, loss of coordination and memory problems, as well as severe headaches combined with dizziness, tremor, palpitations and fear occur after 20-30 mins. After 4 h severe chest pain can occur, lasting for several hours [...] a dose of 1.8 g is reputed to have resulted in several hours’ loss of consciousness (Wink et al., 2008)."
    -"scientific assessment of yohimbe", http://ec.europa.eu/food/food/labellingnutrition/vitamins/sa_yohimbe_en.pdf

    bark extracts can be bought in various forms, but, "a study conducted by Betz et al (1995) showed that extracts contain a maximum of 7% of the yohimbine detectable in the bark, with the majority of products having a significantly lower to zero detectable yohimbine content. the authors explain this by the very high rate of dilution of the end-product and by watery extraction methods."
    -"scientific assessment of yohimbe", http://ec.europa.eu/food/food/labellingnutrition/vitamins/sa_yohimbe_en.pdf

    you can't be sure there will be any yohimbine in them. and if there is, 7% is all you'll get. capsules are being sold with either 450mg or 500mg yohimbe bark extract.

    assuming you'd buy the 500mg variant, and assuming you'd be lucky (= there's 7% yohimbine), then 35mg of yohimbine would be in each capsule. 52 of them would add up to 1.82g. there would still be no guarantee that it'll work for you.
    you'd have to make a test-run first.

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  3. as a means to induce sleep it might then be of use. but you'd still need the other part of your method of choice, that'll do the killing.

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  4. humulus lupulus,"is a sedative and therefore has sleep-inducing effect. this effect, however, strongly depends on the quality of the extract used"
    -"PDR for herbal medicine", p.400

    extracts can be bought from herbal medicine suppliers. if your sleep will be deep enough to stay asleep even when in pain, is not clear.

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